Cancer evolves dynamically as clonal expansions supersede one another, driven by shifting selective pressures,...
The Ghent University Multidisciplinary Research Platform ‘From Nucleotides to Networks (N2N)’ is a center of excellence in state-of-the-art bioinformatical tools and methods with applications in the fields of Sustainable Agriculture and Successful Ageing, recognized worldwide as key challenges for a sustainable society.
It was established by Ghent University in 2011 as part of the strategic spearhead research policy plan promoting excellence in research, selected on the basis of the established expertise and the potential to become world leader in the field. Because of the growing importance of bioinformatics, computational biology, and systems biology in the life sciences, bioinformatics was one of the topics that were selected.
Background: Cost effective next generation sequencing technologies now enable the production of genomic datasets for many novel planktonic eukaryotes, representing an understudied reservoir of genetic diversity. O. tauri is the... Read more
Enzyme sequences and structures are routinely used in the biological sciences as queries to search for functionally related enzymes in online databases. To this end, one usually departs from some notion of similarity, comparing two enzymes by... Read more
Understanding the mechanisms underlying gene regulation is paramount to comprehend the translation from genotype to phenotype. The two are connected by gene expression, and it is generally thought that variation in transcription factor (TF)... Read more
A single eukaryotic gene can give rise to a variety of protein forms (proteoforms) as a result of genetic variation and multilevel regulation of gene expression. In addition to alternative splicing, an increasing line of evidence shows that... Read more